Dr. Kyle Schachtschneider traveled to Dublin for the 36th International Society for Animal Genetics Conference to present the poster entitled: Expression of identical genetic mutations across Oncopig cell types results in distinct expression profiles recapitulating transcriptional hallmarks of human tumors. The poster was selected for an Excellent Poster Award.
In summary, this work showed that:
- Expression of identical genetic mutations (KRASG12D and TP53R167H) across Oncopig cell types results in distinct expression profiles recapitulating transcriptional hallmarks of human tumor types.
- HCC samples demonstrated TERT reactivation, apoptosis evasion, angiogenesis activation, altered cell cycle regulation, and Wnt signaling activation.
- Soft tumor sarcoma tissues showed altered TP53 signaling, Wnt signaling activation, and epigenetic reprogramming.
- The porcine tumors have altered master regulators previously implicated in human STS and HCC development.
In conclusion, these results demonstrate the value of the Oncopig cancer model for modeling of distinct human cancer subtypes. The full abstract and poster can be found here.